早孕妇女血清β-绒毛膜促性腺激素、人胎盘生乳素与多胎关系

Relationship between levels of β-HCG，HPL and multiple pregnancies in early pregnant women

摘要:

目的：通过对早孕多胎妇女血清中β-绒毛膜促性腺激素（Ｂeta-human chorionic gonadotropin，β-HCG）、人胎盘生乳素（Human placental lactogen，HPL）的测定，探讨其与多胎的关系。方法：动态监测门诊18例早孕多胎（包括2胎和3胎）妇女血清β-HCG、HPL的变化，随机选取同期本院门诊正常单胎早孕妇女35例作为对照，从孕5周开始，每２周检查１次血清β-HCG、HPL水平，至孕11周，观察相同孕周２组之间β-HCG、HPL的变化。结果：孕5～9周，多胎组血清β-HCG明显高于单胎组，差异有统计学意义（P＜0.05）；孕11周时，多胎组和单胎血清β-HCG差异无统计学意义（P ＞0.05）；孕5周时，多胎组和单胎组HPL值差异无统计学意义（P ＞0.05）。孕7～11周，多胎组血HPL明显高于单胎组，差异有统计学意义（P＜0.01）。结论：早孕时如β-HCG明显增高，结合HPL升高，应警惕多胎妊娠。

Abstract:

Objective：To explore the relationship between β-human chorionic gonadotropin（β-HCG），human placental lactogen（HPL） and multiple pregnancies by measuring β-HCG and HPL in early pregnant women. Methods：The serum levels of β-HCG and HPL in 18 women with multiple pregnancies（including two and three fetuses） were measured every two weeks from the 5th week of pregnancy to the 11th week; other 35 women with single fetus in the same period were taken as controls. Results：The serum level of β-HCG was significantly higher in multiple pregnancies group than in single pregnancy group during the 5-9th week of pregnancy （P<0.05）. There was no significant difference in serum level of β-HCG between the two groups at the 11th week of pregnancy（P >0.05）. The serum level of HPL was not significantly different between the two groups at the 5th week of pregnancy（P >0.05）. The serum HPL was significantly higher in multiple pregnancies group than in single pregnancy group（P<0.01） during the 7-11th week of pregnancy. Conclusion：Obvious increase of β-HCG and HPL in early pregnancy indicates multiple pregnancies，which should be alerted.