注射用骨肽治疗老年桡骨远端骨折的临床研究

Ossotide for injection in treatment of distal radius fracture

摘要:

目的：探讨外源性骨诱导生长因子（注射用骨肽）治疗老年桡骨远端骨折的临床疗效。方法：收集本院治疗的74例老年桡骨远端骨折患者，随机分为2组，治疗组给予注射用骨肽30 mg静滴；对照组给予碳酸钙片口服。观察骨密度、骨代谢相关生化指标变化以及促进骨折愈合疗效。结果：所有病例随访6～8个月，平均7.1个月，治疗后2月，治疗组血清骨碱性磷酸酶（Bone alkaline phosphatase，BALP）、Ⅰ型前胶原羧基端肽（Procollagen type Ⅰ carboxyterminal propeptide，PICP）、骨钙素（Bone gla protein，BGP）及健侧桡骨骨密度水平明显高于对照组（P<0.05）；治疗组平均愈合时间以及治疗有效率明显高于对照组（P <0.05）。结论：注射用骨肽治疗老年桡骨远端骨折可提高骨诱导能力，增加骨量，促进骨折愈合。

Abstract:

Objective：To explore the curative effect of ectogenesis osteoinduction growth factor（ossotide for injection） in treatment of distal radius fracture. Methods：Totally 74 cases of distal radius fracture were randomly divided into treatment group and control group. Ossotide for injection（30 mg） was used in treatment group while calcium carbonate tablets were used in control group. Bone density，biochemical indicator of bone metabolism and fracture recovery were measured. Results：All cases were followed up for 6-8 months（7.1 months in average）. Serum bone alkaline phosphatase（BALP），procollagen typeⅠcarboxyterminal propeptide（PICP），bone gla protein（BGP） and bone density of healthy radius were significantly higher in treatment group than in control group at 2 months after treatment（P<0.05）. The average recovery time was （8.5±2.7） weeks in treatment group，significantly higher than that of （11.8±3.1） weeks in control groups. The effective rate was 85.3%，significantly higher than that of 28.9% in control group（P<0.05）. Con－clusions：Ossotide for injection can increase bone inducibility and bone mass and enhance fracture recovery for elderly patients.