心力衰竭生物学标志物的临床意义及研究进展

Research progress and clinical significance of biological markers in heart failure

摘要:

心力衰竭是大多数心脏疾病的终末期表现，其生物学标志物能够反映心力衰竭病理发展过程中不同程度及不同方面的变化，对于心力衰竭的诊断、治疗及预后评判具有重要的临床意义。近年随着研究的进展，发现了许多新的标志物，但不同的标志物目前对于临床实践的指导意义不同。本文主要结合最新的国内外临床诊治指南及相关研究进展对心力衰竭的生物学标志物作一系统综述，重点评述此类标志物对目前临床实践的指导价值以及未来在心衰诊断、风险评估、指导治疗、预后评价和早期预警等方面的应用前景。

Abstract:

Heart failure is the end stage of most cardiac diseases. Biomarkers can indicate pathological changes in different stages and aspects during development of heart failure. They have significant roles in the diagnosis，treatment and prognosis of heart failure. In recent years，many studies have revealed some new biomarkers in heart failure. However，different biomarkers have different clinical significance. Based on latest guidelines and recent reports of heart failure，this review summarizes most of biomarkers in heart failure，focusing on their clinical value and prospects to be used widely in the early diagnosis，proper treatment and prognosis assessment of heart failure.