宫颈癌患者卵巢移位术后接受放疗对卵巢功能影响研究

Effect of radiotherapy on ovarian function after ovarian transposition in patients with cervical cancer

摘要:

目的：探讨宫颈癌患者卵巢移位术后放疗对卵巢功能的影响。方法：收集2015—2019年重庆大学附属肿瘤医院收治的51例Ⅰ期至Ⅲ期宫颈癌行卵巢移位术及放疗的患者资料。其中5例患者进展，5例患者失访。随访患者术后情况，采用改良的围绝经期综合征量表（改良Kupperman评分表）评分，观察其卵巢功能受损症状情况及性生活情况。结果：按年龄（≥40岁和<40岁）、手术方式（开腹根治、腹腔镜根治、腹腔镜分期术）、术后时间（≥1年、<1年）分组，患者卵巢功能受损与年龄及术后时间无统计学意义。开腹根治与腹腔镜根治、腹腔镜根治与腹腔镜分期术后卵巢功能受损无统计学差异，开腹根治与腹腔镜分期存在统计学差异（P<0.05）。少部分患者（18%）有性生活，极少部分患者对性生活满意（6%）。结论：卵巢移位术后卵巢功能改变与年龄、术后时间无关，可能与手术方式有关。卵巢移位术后保留卵巢功能对年轻患者生活质量非常重要。

Abstract:

Objective：To investigate the effect of radiotherapy on ovarian function in patients with cervical carcinoma after ovarian transposition. Methods：Data of 51 patients with stage Ⅰ-Ⅲ cervical carcinoma undergoing ovarian transposition and radiotherapy in our hospital from 2015 to 2019 were collected. Among those patients，5 patients showed progression and 5 patients lost follow-up. The postoperative condition were followed up，the modified Perimenopausal Syndrome Scale（modified Kupperman scale） was used to give score，and ovarian dysfunction and sexual life were observed. Results：Grouping based on age（≥ 40 years old and < 40 years old），operative way（radical laparotomy，laparoscopic radical operation and laparoscopic staging） and postoperative time（≥1 year and < 1 year） showed there was no statistical significance between ovarian dysfunction and age，as well as postoperative time. There were no significant differences in postoperative ovarian dysfunction between radical laparotomy and laparoscopic radical operation，as well as laparoscopic radical operation and laparoscopic staging（P<0.05）. A few patients（18%） had sexual life，and a very few patients（6%） were satisfied with sexual life. Conclusion：The change of ovarian function after ovarian transposition is not related with age and post－operative time，but may be related with operative ways. The preservation of ovarian function after ovarian transposition is very impor－tant for the life quality of young patients.