心脏脂肪沉积与心血管疾病关系的研究进展

Research progress of cardiac fat deposition and cardiovascular disease

摘要:

心血管疾病（cardiovascular disease，CVD）已成为造成残疾和死亡的主要原因。肥胖作为CVD的重要危险因素，在CVD管理中受到广泛关注。然而，并非所有的脂肪组织都有相同的炎症、分泌和代谢活动。最新研究表明，心脏脂肪的沉积与心脏代谢风险的增加尤为相关。通过超声、计算机断层扫描（computed tomography，CT）和磁共振成像（magnetic resonance imaging，MRI）等无创性成像技术，可定性定量地反映心脏脂肪的沉积情况，为心血管风险评估发挥临床作用。据此，本文综述了无创性测量心脏脂肪的方法、心脏脂肪沉积的特点及其影响CVD的相关机制，为防治心血管风险进展提供重要依据。

Abstract:

Cardiovascular disease（CVD） has become the main cause of disability and death. Obesity，as an important risk factor for CVD，has received widespread attention in the management of CVD. However，not all adipose tissues have the same inflammatory，secretory，and metabolic activities. The latest research shows that cardiac fat deposition is particularly associated with increased risk of heart metabolism. Noninvasive imaging techniques such as ultrasound，computed tomography（CT） and magnetic resonance imaging（MRI），which play a clinical role in cardiovascular risk assessment，can qualitatively and quantitatively reflect cardiac fat deposition. Therefore，this paper has reviewed the methods of noninvasive measurement and the characteristics of cardiac fat deposition，as well as the related mechanisms affecting CVD，so as to provide an important basis for the prevention and treatment of cardiovascular risk.