Sestrin2在心血管病变中的研究进展

Research pregress of Sestrin2 in cardiovascular diseases

摘要:

Sestrin2（Sesn2）是一种高度保守的应激诱导蛋白，属于Sesns家族，其表达受DNA损伤、氧化应激和缺氧等诱导而上调。上调后的Sesn2作为抗氧化剂，在多种生理和病理条件下发挥保护作用。本综述阐述了调节因子p53、核因子E-2-相关因子2（nuclear factor-erythroid 2-related factor 2，Nrf2）和低氧诱导因子-1（hypoxia inducible factor-1，HIF-1）等会诱导Sesn2的表达，而Sesn2会调节下游磷酸腺苷活化蛋白激酶（AMP-activated protein kinase，AMPK）/哺乳动物雷帕霉素靶蛋白（mammalian target of rapamycin，mTOR）和自噬信号在心脏血管类病变中发挥重要作用。本综述旨在全面了解Sesn2在心脏和血管等病变中的保护作用。

Abstract:

Sestrin2（Sesn2），a member of the Sesns family，is a highly conservative stress-induced protein，which can be up-regulated by DNA damage，oxidative stress and hypoxia. The up-regulated Sesn2 acts as an antioxidant and exerts protection effect under a variety of physiological and pathological conditions. This review has described that the regulatory factor p53，nuclear factor-erythroid 2-related factor 2（Nrf2） and hypoxia inducible factor-1（HIF-1） is able to induce the expression of Sesn2，while Sesn2 can regulate downstream AMP-activated protein kinase（AMPK）/mammalian target of rapamycin（mTOR） and autophagy signals，playing an impor－tant role in cardiovascular and metabolic diseases. This review aims to provide a comprehensive understanding of the protective role of Sesn2 in diseases of heart and blood vessels.