lncRNA/microRNA调控中枢神经系统损伤后神经干细胞增殖的研究进展

lncRNA/microRNA regulating the proliferation of neural stem cells after central nervous system injury

摘要:

非编码RNA（non-coding RNA，ncRNA）作为影响神经干细胞增殖的潜在靶点，近年来已成为研究改善中枢神经系统损伤的关键影响因素。虽然神经干细胞在成体神经组织中不易增殖，但由于ncRNA具有调控细胞更新的作用，且微小RNA（microRNA，miRNA）与长链非编码RNA（long non-coding RNA，lncRNA）之间作用方式具有复杂性与多样性，因此近年来二者成为调控神经干细胞增殖的研究热点。本文总结近年来miRNA、lncRNA及miRNA与lncRNA共同作用如何影响神经干细胞的增殖，并就目前研究的局限性进行深入分析，并阐述康复医学领域通过物理因子介导神经干细胞增殖的研究，为将来相关领域的研究提供方向。

Abstract:

As a potential target that affects the proliferation of neural stem cells，non-coding RNA（ncRNA） has become a key influ－encing factor to improve the damage of central nervous system in recent years. Although neural stem cells are not easy to proliferate in adult neural tissues，ncRNA has the effect of regulating cell renewal，and the interaction between microRNA（miRNA） and long non-coding RNA（lncRNA） is complex and diverse. Therefore，in recent years，the two have become the hot spots of the study of regulating the proliferation of neural stem cells. This article summarizes how miRNA，lncRNA，and the combined effects of miRNA and lncRNA affect the proliferation of neural stem cells in recent years，and conducts an in-depth analysis of the limitations of current research，focusing on the studies of physical agents mediated neural stem cell proliferation in the field of rehabilitation medicine，providing a direction for future research in related fields.