脑梗死合并2型糖尿病的认知障碍危险因素

Risk factors for cognitive dysfunction in patients with brain infarction and type 2 diabetes

摘要:

目的 探讨脑梗死合并2型糖尿病（type 2 diabetes，T2D）患者发生认知障碍的危险因素，为认知障碍的临床诊疗提供一定思路。方法 回顾性收集2010年1月至2021年12月于空军军医大学西京医院入院的脑梗死合并T2D的患者资料，将符合入组条件的191例患者根据简易精神状态检查分为认知障碍组（CD组）和认知正常组（Non-CD组），对患者的一般特征、临床特征和生化检验资料进行分析。结果 单因素分析显示，年龄、教育程度、依赖程度、糖尿病病程、D-二聚体、纤维蛋白原降解产物与认知障碍显著相关（P<0.05）。多因素logistic回归和ROC曲线分析显示，年龄（OR=2.249，95%CI=1.172~4.319，P=0.015）和教育程度（OR=0.587，95%CI=0.352~0.978，P=0.041）与脑梗死合并T2D发生认知障碍的显著危险因素。结论 年龄和教育程度与脑梗死合并T2D密切相关，也是其发生认知障碍的有效危险因素。

Abstract:

Objective To identify the risk factors for cognitive dysfunction in patients with brain infarction and type 2 diabetes（T2D），and to offer insights for the diagnosis and treatment of cognitive dysfunction.Methods In this retrospective study，data were collected from patients with brain infarction complicated with T2D，who were admitted to Xijing Hospital，Air Force Medical University from January 2010 to December 2021. A total of 191 eligible patients were divided into cognitive dysfunction group（CD group） and non-cognitive dysfunction group（Non-CD group） according to mini-mental state examination. Data were collected on demographic characteristics，clinical features，and biochemical markers.Results The univariate analysis showed significant correlations of cognitive dysfunction with age，education level，degree of dependence，duration of T2D，D-dimer，and fibrinogen degradation products（P<0.05）. The multivariate logistic regression and receiver operating characteristic curve showed that age（OR=2.249，95%CI=1.172-4.319，P=0.015） and education level（OR=0.587，95%CI=0.352-0.978，P=0.041） were significant risk factors for cognitive dysfunction in patients with brain infarction and T2D.Conclusion Age and education level are tightly related to brain infarction and T2D，and are risk factors for cognitive dysfunction.