生活方式与家族史对心血管代谢疾病的交互作用分析

Interaction between lifestyle and family history on cardiometabolic diseases

摘要:

目的 探讨生活方式与心血管代谢疾病家族史（以下简称家族史）对心血管代谢疾病患病的影响及两者的交互作用，指导疾病防控。方法 按照纳入排除标准选取合川区3 009例30~79岁常住居民作为调查对象，进行问卷调查、体格检查及实验室检测。运用SPSS 26.0进行χ²检验和多因素logistic回归分析，采用相乘模型和相加模型分析生活方式与家族史对心血管代谢疾病患病的交互作用。结果 生活方式和家族史对心血管代谢疾病患病，既不存在相乘交互作用（OR_int=1.22，95%CI=0.86~1.73），也不存在相加交互作用，相对超危险度比（the relative excess risk due to interaction，RERI）、归因比（attributable risk percent，AP）、交互作用指数（S）分别为0.69（95%CI=-3.98~5.36）、0.21（95%CI=-0.95~1.37）、1.44（95%CI=0.16~13.03）。生活方式不健康且有家族史者，患心血管代谢疾病的风险高于生活方式健康且无家族史者（OR=3.26，95%CI=2.52~4.23），男性（OR=5.16，95%CI=3.12~8.52）远高于女性（OR=2.72，95%CI=1.96~3.77）。结论 生活方式和家族史对心血管代谢疾病患病风险不存在交互作用，但存在联合作用。有家族史者保持健康生活方式，有利于控制心血管代谢疾病患病。

Abstract:

Objective To investigate the influence of lifestyle and family history of cardiometabolic diseases on the risk of cardiometabolic diseases and the interaction between lifestyle and family history，and to guide disease prevention and control.Methods A total of 3009 permanent residents，aged 30-79 years，in Hechuan District were selected as subjects according to the inclusion and exclusion criteria，and a questionnaire survey，physical examination，and laboratory tests were performed. SPSS 26.0 was used to perform the chi-square test and the multivariate logistic regression analysis，and the multiplicative model and the additive model were used to investigate the interaction between lifestyle and family history on the onset of cardiometabolic diseases.Results There was neither multiplicative interaction（OR_int=1.22，95%CI=0.86-1.73） nor additive interaction between lifestyle and family history on cardiometabolic diseases，with a relative excess risk due to interaction of 0.69（95%CI=-3.98 to 5.36），an attributable proportion of 0.21（95%CI=-0.95 to 1.37），and a synergy index of 1.44（95%CI=0.16-13.03）. The individuals with an unhealthy lifestyle and a family history of cardiometabolic diseases had a higher risk of cardiometabolic diseases than those with a healthy lifestyle and no family history（odds ratio[OR]=3.26，95%CI=2.52-4.23），and male individuals（OR=5.16，95%CI=3.12-8.52） had a higher risk than female individuals（OR=2.72，95%CI=1.96-3.77）.Conclusion There is no interaction between lifestyle and family history on the risk of cardiometabolic diseases，but there is a combined effect. For individuals with such family history，maintaining a healthy lifestyle may help to control cardiometabolic diseases.