TNF-α-308G/A基因多态性与慢性牙周炎易感性关系的Meta分析

TNF-α-308 G/A gene polymorphism and risk of chronic periodontitis：a Meta analysis

摘要:

目的：探讨肿瘤坏死因子-α-308（tumor necrosis factor-alpha-308，TNF-α-308）基因多态性与慢性牙周炎（chronic pe－riodontitis，CP）易感性的关系。方法：计算机检索PubMed、EMbase、CNKI、CBM、VIP 和万方数据，检索时限均为建库至2013年10月。按照纳入与排除标准筛出关于TNF-α-308G/A基因多态性与CP易感性相关的病例-对照研究或队列研究。对纳入研究采用Newcastle-Ottawa 量表进行质量评价。采用RevMan 5.2.0 和Stata 12.0 软件进行统计分析。结果：共纳入18个研究，1 420例CP患者，1 538例健康对照。Meta分析结果显示：①TNF-α-308G/A基因多态性与CP相关性：等位基因遗传模型A vs. G（OR=1.05，95%CI＝0.83～1.34，P=0.68）、加性遗传模型AA vs. GG（OR=1.35，95%CI＝0.78～2.34，P=0.28）、显性遗传模型AA+AG vs. GG（OR=1.02，95%CI＝0.79～1.33，P=0.88）、隐性遗传模型AA vs. AG+GG（OR=1.42，95%CI＝0.82～2.45，P=0.21）；②以人种、严重程度、吸烟情况为亚组进行分层分析，结果显示TNF-α-308 位点的多样性在不同人群中也无明显相关性（P >0.05）。结论：现有证据显示，TNF-α-308基因多态性可能与CP易感性无关。由于纳入研究数量有限，上述结论尚需开展更多高质量、大样本的随机对照试验加以验证。

Abstract:

Objective：To evaluate the association between TNF-α-308 G/A gene polymorphism and the risk of chronic periodontitis（CP）. Methods：A Meta analysis was performed to analyze the association between TNF-α-308 gene polymorphism and the risk of CP. Studies on correlation between TNF-α-308 G/A gene polymorphism and susceptibility to CP were systematically retrieved from PubMed，Embase，CNKI，CBM，VIP and WanFang Data. Academic level of studies included in this article was assessed according to the Newcastle-Ottawa Scale（NOS）. Meta analysis was carried out using the Review Manager（version 5.2.0） and Stata（version 12.0）. Results：A total of 18 case-control studies（1 420 cases，1 538 controls） were included in this Meta analysis. The results showed no statistically significant difference in all genotype models between CP cases and controls：allele genetic model A vs. G（OR=1.05，95%CI=0.83 to 1.34，P=0.68），additive genetic model AA vs. GG（OR=1.35，95%CI=0.78 to 2.34，P=0.28），dominant model AA+AG vs. GG （OR=1.02，95%CI=0.79 to 1.33，P=0.88），recessive model AA vs. AG+GG（OR=1.42，95%CI=0.82 to 2.45，P=0.21）. In the subgroup analysis by ethnicity，severity and smoking status，no statistically differences was found between CP cases and controls（P >0.05）. Conclusion：TNF-α-308G/A gene polymorphism may not be a risk factor of CP. Due to the limited quantity of the included studies；further studies are needed to validate the above conclusion.