关节软骨微环境的物质输运研究进展

Research progress of solute transport in the microenvironment of articular cartilage

摘要:

关节软骨是最常见且研究最多的一种透明软骨；其软骨细胞的物质输运主要由扩散和对流2种方式完成。在关节软骨的胞外基质内，生物活性分子的扩散和对流输运在组织生理调节和细胞生物学响应中起到极为重要的作用。近年来，关节软骨与软骨下骨的交互作用备受关注；其交互作用在骨关节炎的发生发展中不容忽视。本文主要对关节软骨内、关节软骨与软骨下骨间物质输运的实验研究进展进行综述，旨在为研究关节软骨微环境的生理病理作用提供一定参考，并为临床治疗骨关节炎提供一定的新思路。

Abstract:

Articular cartilage is the most common hyaline cartilage which has been studied the most. The solute transport of chondrocytes includes diffusion and convection. In the extracellular matrix, diffusion and convection of bioactive molecule plays an important role in physiologic adjustment and cytobiological response. For the last few decades, the interaction of subchondral bone and articular cartilage has been investigated, which is considered as an important aspect in the etiology of osteoarthritis. In this paper, we have reviewed studies of solute transport in articular cartilage and the interface of cartilage and subchondral bone, aiming to provide references to environmental pathophysiological function of articular cartilage and provide new thoughts for treating clinical ostearthritis.