回顾性分析血尿素在甲状腺良恶性肿瘤中的表达情况

Retrospective analysis of expression of blood urea nitrogen in benign and malignant thyroid tumors

摘要:

目的： 探讨血尿素在分化型甲状腺癌和甲状腺良性肿瘤中的表达情况，以评估尿素代谢异常在二者中有无差异。方法： 选取病理明确的无肝肾疾病分化型甲状腺癌患者218例（A组）和甲状腺良性肿瘤患者193例（B组）为研究对象，均于术前1～3 d检测血尿素水平。采用t检验分析2组尿素水平差异；多因素方差分析评估年龄、性别、肿瘤性质等对尿素水平影响；GEPIA数据库检测尿素循环相关基因在甲状腺癌及正常组织中的表达。结果： 去除慢性淋巴细胞性甲状腺炎的影响，A组血尿素水平高于B组（P>0.05）。男性>55岁是血尿素水平升高的影响因子，而淋巴结转移状态对其无明显影响。TP53和MDM2基因在甲状腺癌中表达升高，但差异无统计学意义。结论： 男性、高龄甲状腺肿瘤患者出现尿素代谢异常的可能性更高。

Abstract:

Objective: To investigate the expression of blood urea nitrogen in differentiated thyroid cancer and benign thyroid tumors, so as to evaluate the difference of urea cycle dysregulation between them. Methods: A total of 218 patients with diagnosis of differentiated thyroid cancer were enrolled in the group A and 193 patients with benign thyroid tumors in the group B. Blood urea nitrogen levels were measured 1-3 days before surgery.T test was used to analyze differences of urea nitrogen levels in two groups and two-way ANOVA analysis of variance was used to assess the effects of age, gender and tumor properties on urea nitrogen levels. The expression of genes related to urea cycle was evaluated by GEPIA database. Results: After excluding chronic lymphocytic thyroiditis, the urea nitrogen level in the group A was significantly higher than that in the group B (P>0.05). Males' age>55 years old was the factor for elevating nitrogen levels, while the metastasis status of lymph node was not an influencing factor. The expression of TP53 and MDM2 in the cancer tissue was higher, without significant differences. Conclusion: Males older than 55 years old are more likely to have dysregulation of urea metabolism.