脑梗死出血转化生物学标志及预测研究进展

Advances in research on biomarkers and prediction of cerebral infarction hemorrhage transformation

摘要:

在缺血性中风的发病机制中，由于内皮细胞等血脑屏障结构破坏、再灌注损伤、溶栓药治疗后凝血功能障碍等，恢复的血流从破坏的血管进入脑组织中，称为出血转化（haemorrhagic transformation，HT）。严重的HT是导致患者死亡的原因之一。研究发现多种因素可能与HT有关，如高龄、糖尿病、患者病情严重等。能否由生物学标记物定量确定HT概率，并通过管理减少HT，将为临床HT的防治提供帮助。为此，本文就该方面的研究进展进行综述。

Abstract:

In the pathogenesis of ischemic stroke, due to the breakdown of blood-brain barrier structures such as endothelial cells, reperfusion injury, and coagulation dysfunction after thrombolytic therapy, etc., the restored blood flow enters the brain tissue from the damaged blood vessels, which is called hemorrhagic transformation (HT). Severe HT is one of the causes of death in patients. Researches find that HT may be related to many factors, such as venerable age, diabetes, and the severity of the patient's condition. It will be helpful for the prevention and treatment of clinical HT whether the probability of HT can be determined quantitatively by biological markers and reduced by management. Therefore, this paper reviews the advances in this area.