脑出血后激活PPAR-γ对继发性脑损伤的治疗价值研究进展

Research progress on therapeutic value of activating peroxisome proliferator-activated receptor-gamma on secondary brain injury after intracerebral hemorrhage

摘要:

脑出血发生数小时至数天内，由红细胞裂解产物引起的氧化反应、炎症反应及线粒体功能障碍将导致继发性脑损伤。过氧化物酶增殖物激活受体-γ（peroxisome proliferator-activated receptor-gamma，PPAR-γ）在内源性血肿清除系统中发挥多重作用，激活PPAR-γ后不仅在抗炎抗氧化方面发挥作用，还在介导吞噬细胞清除血肿方面发挥作用，因此激活PPAR-γ可能是治疗脑出血后继发性脑损伤的一个潜在靶点。

Abstract:

Oxidative reaction, inflammatory action, and mitochondrial dysfunction caused by erythrocyte lysates will lead to secondary brain injury within hours to days of cerebral hemorrhage. It has been found recently that peroxisome proliferator-activated receptorgamma (PPAR-γ) plays multiple roles in endogenous hematoma clearance systems. When PPAR-γ is activated, it not only plays a role in anti-inflammatory and anti-oxidation, but also mediates the role of phagocytic cells in clearing hematoma to protect neurons. Therefore, PPAR-γ may be a potential target for the treatment of secondary brain injury after intracerebral hemorrhage.