卵巢恶性肿瘤合并静脉血栓栓塞症的因素分析

Investigation of risk factors for venous thromboembolism in women with ovarian malignant tumor

摘要:

目的： 研究卵巢恶性肿瘤患者发生静脉血栓栓塞症（venous thromboembolism，VTE）的危险因素。方法： 回顾性分析2015年1月1日至2018年6月30日中山大学孙逸仙纪念医院妇科肿瘤专科收治的345例卵巢恶性肿瘤患者资料，其中31例发生VTE，314例未发生VTE。比较卵巢恶性肿瘤患者的年龄、身高、体质量、病理分期、病理类型、肿瘤标志物水平等，以研究卵巢恶性肿瘤患者发生静脉血栓的危险因素。结果： 卵巢恶性肿瘤合并VTE组与无VTE组的年龄和手术病理分期差异有统计学意义（P<0.05）；体质指数（body mass index，BMI）、病理类型的差异无统计学意义（P>0.05）。2组血肿瘤标志物（AFP、CEA、CA125、CA199、CA724、HE4）水平差异均无统计学意义（P>0.05）。Logistic分析提示手术病理分期是卵巢恶性肿瘤合并VTE的独立危险因素。结论： 年龄和分期是卵巢恶性肿瘤合并VTE的危险因素，对年龄大以及肿瘤晚期的患者应重点预防和监测血栓的发生。

Abstract:

Objective: To clarify the risk factors for venous thromboembolism (VTE) in women with ovarian malignant tumor. Methods: The data of 345 patients with ovarian malignant tumor admitted to the department of gynecological oncology of Sun Yat-sen Memorial Hospital, Sun Yat-sen University from January 1, 2015 to June 30, 2018 were analyzed retrospectively, among which 31 cases had VTE and 314 cases didn't. The patients'age, height, weight, surgical-pathological stage, pathological type and level of tumor markers were compared, so as to study the risk factors of VTE in patients with ovarian malignant tumor. Results: Our analysis showed that there were significant differences in surgical-pathological stage and age among the ovarian malignant tumor patients with VTE and those without (P<0.05), and there was no significant difference between body mass index (BMI) and pathology type (P>0.05). There was also no significant difference among tumor markers (AFP, CEA, CA125, CA199, CA724, HE4) (P>0.05).Logistic analysis suggested that surgical-pathological stage was an independent risk factor of VTE in women with ovarian malignant tumor. Conclusion: Age and surgical-pathological stage are risk factors of VTE in women with ovarian malignant tumor. The prevention and monitoring of thrombosis should be focused on the elderly and patients with advanced tumor.