心肌酶谱三项对儿童重症腺病毒肺炎的诊断价值分析

Diagnostic value of three items of myocardial enzyme spectrum in children with severe adenovirus pneumonia

摘要:

目的： 探讨血乳酸脱氢酶（lactate dehydrogenase，LDH）、谷草转氨酶（aspartate aminotransferase，AST）与肌酸激酶同工酶（creatine kinase isoenzyme，CK-MB）在儿童重症腺病毒肺炎（severe adenovirus pneumonia，SAP）诊断中的价值。方法： 将2018年1月1日至2019年12月31日在江西省儿童医院呼吸科诊断为腺病毒肺炎的159例患儿根据病情严重程度分为普通腺病毒肺炎组和重症腺病毒肺炎组。比较2组血LDH、AST和CK-MB水平；采用受试者工作曲线（receiver operating curve，ROC曲线）比较三者对重症腺病毒肺炎的检验效能大小。结果： 与普通腺病毒肺炎患儿比较，重症患儿血清中LDH、AST和CK-MB较高，差异均具有统计学意义（P<0.05），ROC曲线显示LDH对重症腺病毒肺炎的诊断效能最好。结论： 血LDH、AST和CK-MB水平升高对提示重症腺病毒肺炎有很大帮助，尤其要关注血LDH变化。

Abstract:

Objective: To investigate the value of blood lactate dehydrogenase (LDH), aspartate aminotransferase (AST) and creatine kinase isoenzyme (CK-MB) in the diagnosis of severe adenovirus pneumonia (SAP) in children. Methods: A total of 159 children diagnosed with adenovirus pneumonia in the respiratory department of our hospital from January 1, 2018 to December 31, 2019, were divided into the ordinary adenovirus pneumonia group and the SAP group according to the severity of their condition. The levels of LDH, AST and CK-MB in blood were compared between the two groups, and the receiver operating curve (ROC curve) was used to compare the test efficiency of the three for SAP. Results: Compared with children with ordinary adenovirus pneumonia, the serum levels of LDH, AST and CK-MB in severe children were higher, and the differences were statistically significant (P<0.05). The ROC curve showed that LDH had the best diagnostic efficiency for SAP. Conclusion: Increased serum levels of LDH, AST and CK-MB are of great help to diagnose SAP, especially the changes in blood LDH.