肠道微生物紊乱诱导抑郁的肠-脑分子机制研究

Study of gut microbiota dysbiosis induced depression and the underlying gut-brain mechanisms

摘要:

抑郁症（major depressive disorder，MDD）是一种严重影响人类健康的重大精神疾病。越来越多的研究显示肠道微生物紊乱在MDD发病过程中具有重要调节作用。本课题组针对MDD存在的肠道微生物紊乱、引起MDD发病的关键肠道微生物、肠道微生物紊乱诱发MDD的肠-脑分子机制开展了系列研究，本文就课题组已取得的研究进展作一综述。

Abstract:

Major depressive disorder (MDD) is a major mental disease which seriously affects human health. Increasing researches have shown that dysbiosis of gut microbiota plays an important role in the pathogenesis of MDD. We have carried out a series of researches to uncover the dysbiosis of gut microbiota in MDD and identify the key gut microflora that cause MDD, as well as the underlying molecular mechanisms. The present manuscript summarizes the research findings of our research group.