亲代代谢异常对子代代谢的影响及机制

The effect and mechanism of abnormal metabolism in parents on metabolism of offspring

摘要:

代谢编程是指在人类和其他哺乳类动物胚胎期及分娩后各重要器官发育成熟的关键阶段。营养及其他环境因素能改变生物体内的表观遗传特征，从而影响这些器官的正常发育和成熟，使其在器官发育、物质代谢、免疫应激等方面发生相应改变，最终导致功能和代谢的永久改变，增加成年后多种慢性疾病发病的易感性。由于代谢编程异常的不利结局存在于两代人中间，并可能在“亲代—子代—亲代”之间形成恶性循环，所以其影响巨大，严重威胁几代人的健康，已成为全世界主要的健康与经济负担。肖晓秋研究团队多年来一直致力于打破这种恶性循环，本文就课题组已取得的研究进展进行工作综述，力图为从源头上控制代谢性疾病的发生和发展提供新的依据。

Abstract:

Metabolic programming means that nutrition and other environmental factors can change the epigenetic characteristics of the organism during the embryonic period and key stages of the development and maturation of vital organs in humans and other mammals, thereby affecting the normal development and maturity of these organs. It makes corresponding changes in organ development, material metabolism, immune stress, etc., which will eventually lead to permanent changes in function and metabolism, and increase the susceptibility of many chronic diseases in adulthood. Because the unfavorable outcome of abnormal metabolic programming exists between two generations, and may form a vicious circle between "parents-offspring-parents". It seriously threatens the health of several generations and has become a major issue in the world. Health and economic burden. Our research team has been committed to breaking this vicious circle for many years. This article reviews the research progress made by the research team and aims to provide a new basis for controlling the occurrence and development of metabolic diseases from the source.