胎球蛋白B对糖脂代谢影响的研究进展

Research progress on the effect of fetuin B on glucolipid metabolism

摘要:

胎球蛋白B作为半胱氨酸蛋白酶抑制剂，在人类代谢疾病、炎症、肿瘤、生殖方面都扮演重要角色。糖脂代谢的紊乱与人体糖尿病、非酒精性脂肪肝等代谢疾病都密切相关。近年有大量关于胎球蛋白B与糖脂代谢的研究。本文旨在对目前的研究进展作一综述，以便更好地理解胎球蛋白B在糖脂代谢中的角色，为代谢疾病的预防、诊断及治疗提供一定思路。

Abstract:

Fetuin B, as a member of the cysteine protease inhibitors, was found to be a critical role in human metabolic disorders, inflammation, tumor and fertilization. The dysregulated of glucolipid metabolism is essentially associated with diabetes, non-alcoholic fatty liver disease and other metabolic disorders. Recent studies have shown that a relationship between fetuin B and glucolipid metabolism, the aim of this review is to summarize the development of the studies, better elucidate the physiological role of fetuin B, as well as provide the new conceptions on prevention, diagnosis, and therapy of metabolic disorders.