胰腺癌疼痛机制研究进展

Research progress on pain mechanism of pancreatic cancer

摘要:

晚期胰腺癌患者往往伴有中到重度疼痛，很大程度上降低了患者的生活质量甚至缩短生存期。早期的神经浸润是导致患者生存期短和中重度疼痛的主要原因，神经肿瘤微环境中各种炎性细胞的参与，不同程度地促进肿瘤细胞的增殖和迁移，随之分子通路中的疼痛信号物质和疼痛通道大量产生，导致患者重度疼痛。随着对各个信号通路研究的深入，神经生长因子及受体通路、趋化因子、疼痛通道和非编码mRNA等都是潜在治疗的靶点。本文对胰腺癌疼痛机制进行总结，为后续机制的研究、治疗靶点的开发提供参考。

Abstract:

Patients with advanced pancreatic cancer are often accompanied by moderate to severe pain, which greatly reduces the quality of life and even shortens the survival time. Early perineural invasion is the main cause of patients'%short survival time and moderate to severe pain. The involvement of various inflammatory cells in neurotumor microenvironment promotes the proliferation and migration of tumor cells to varying degrees, and then pain signal substances and pain channels in molecular pathways are multiply produced, resulting in severe pain in patients. With the further study of various signaling pathways, nerve growth factors and receptor pathways, chemokines, pain channels and non-coding mRNA are potential therapeutic targets. In this paper, the pain mechanism of pancreatic cancer is summarized, which provides reference for the subsequent research on the mechanism and development of therapeutic targets.