重离子辐射旁效应相关调控蛋白及信号通路的研究进展

Research progress on regulatory protein and signaling pathway of heavy ion radiation-induced bystander effects

摘要:

辐射旁效应（radiation-induced bystander effects，RIBE）是指受辐射的细胞通过一定的机制将损伤效应传递给未受辐射的细胞，未受辐射的细胞表现出类似于受辐射细胞的生物损伤效应现象。近年发现，多类调控蛋白及信号通路在重离子辐射旁效应过程中参与细胞凋亡、细胞增殖、细胞周期阻滞等生物学效应。本文就这些调控蛋白及信号通路在重离子辐射旁效应中的作用机制作一综述。

Abstract:

Radiation-induced bystander effects (RIBE) means that radiated cells transmit the damage effect to the irradiated cells through a certain mechanism and irradiated cells show similar biological damage effects to radiated cells. In recent years, many kinds of regulatory proteins and signaling pathways have been found to be involved in apoptosis, proliferation, cell cycle arrest and other biological effects in the process of heavy ion RIBE. This article reviewed the mechanism of these regulatory proteins and signaling pathways in heavy ion RIBE.