Ⅲ型前列腺炎患者前列腺液中血管活性肠肽和肿瘤坏死因子－α的表达及意义

Expression and significance of vasoactive intestinal peptide and tumor necrosis factor-α in prostatic secretion of patients with type Ⅲ prostatitis

摘要:

目的：观察Ⅲ型前列腺炎患者前列腺按摩液（expressed prostatic secretion，EPS）中血管活性肠肽（vasoactive intestinal peptide，VIP）和肿瘤坏死因子－α（tumor necrosis factor-α，TNF-α）的表达，探讨VIP和TNF-α对Ⅲ型前列腺炎临床诊断及疗效判定价值。方法：Ⅲ型前列腺炎患者69例，其中：Ⅲa型37例、Ⅲb型32例，采用ELISA法检测EPS中VIP和TNF-α的含量。结果：Ⅲa、Ⅲb组VIP含量[Ⅲa组（51.33±10.63） pg/ml，Ⅲb组（47.45±7.55） pg/ml]均明显高于正常对照组[（25.95±4.74） pg/ml]；Ⅲa组TNF-α含量[（76.08±15.44） pg/ml]明显高于Ⅲb组[（27.85±6.43） pg/ml]及正常对照组[（10.30±3.62） pg/ml]，Ⅲb组[（27.85±6.43） pg/ml]明显高于正常对照组[（10.30±3.62） pg/ml]，差异均有统计学意义（P＝0.000）。Ⅲ型前列腺炎患者VIP含量变化与慢性前列腺炎症状指数评分呈正相关（r=0.711，P＝0.000）；与国际前列腺症状评分呈正相关（r=0.428，P＝0.000）。结论：VIP、TNF-α在Ⅲ型前列腺炎患者EPS中的表达较正常青年男性显著增高，TNF-α在Ⅲa组及Ⅲb组间存在统计学差异。VIP及TNF-α的检测可能为Ⅲ型前列腺炎的临床诊断和治疗评估提供有价值的参考指标。

Abstract:

Objective：To explore the expression of vasoactive intestinal peptide（VIP） and tumor necrosis factor-α（TNF-α） in ex－pressed prostatic secretions（EPS） of patients with type Ⅲ prostatitis and to discuss the value of VIP and TNF-α in the diagnosis and treatment of type Ⅲ prostatitis. Methods：Sixty-nine patients with type Ⅲ prostatitis were investigated including 37 cases of type Ⅲa and 32 cases of type Ⅲb. Levels of VIP and TNF-α were measured by ELISA. Results：Contents of VIP in EPS were significantly higher in type Ⅲa and type Ⅲb groups（Ⅲa group：（51.33±10.63） pg/ml；Ⅲb group：（47.45±7.55） pg/ml） than in control group（（25.95±4.74） pg/ml）. Contents of TNF-α were significantly higher in type Ⅲa group（（76.08±15.44） pg/ml） than in type Ⅲb group（（27.85±6.43） pg/ml） and control group（（10.30±3.62） pg/ml）；significantly higher in Ⅲb group than in control group with statis－tical differences（P=0.0０0）. Contents of VIP were positively related with NIH-chronic prostatitis symptom index（r=0.711，P=0.000） and international prostate symptom score（r=0.428，P=0.000）. Conclusions：Contents of VIP and TNF-α are significantly higher in type Ⅲ prostatitis groups than in control group. Differences are existed in TNF-α contents between type Ⅲa group and type Ⅲb. Detection of VIP and TNF-α may provide valuable indicators in the diagnosis and treatment of type Ⅲ prostatitis.