犬肾下腹主动脉假性动脉瘤模型的建立

Establishment of infrarenal abdominal aortic pseudoaneurysm model in dogs

摘要:

目的：建立适用于血液动力学研究的犬肾下腹主动脉假性动脉瘤模型，并进行形态学及血液动力学评估。方法：选取健康雌性比格犬14只，其中7只采取传统静脉补片方法建立假性动脉瘤作为对照组，另外7只采取新的“袋状”静脉补片方法建立假性动脉瘤模型作为实验组。并于术后即刻、7、14 d及30 d进行计算机断层扫描血管成像。术后7 d行彩超检查，对其进行形态学及血液动力学评估。结果：实验动物存活率100%。对照组在术后即刻、7、14、30 d时局部管壁扩张率分别为（6.11±2.38）%、（26.14±7.14）%、（63.42±12.77）%、（88.26±14.42）%，实验组在术后即刻、7、14、30 d时局部管壁扩张率分别为（199.39±14.92）%、（216.83±14.68）%、（239.30±16.75）%、（266.30±16.48）%。在各观测点上，实验组较对照组管壁扩张率高，差异有统计学意义。结论：采取“袋状”静脉补片法建立的犬肾下腹主动脉假性动脉瘤的模型在形态学及血液动力学方面更加符合人体假性动脉瘤的特点。

Abstract:

Objective：To establish infrarenal abdominal aortic pseudoaneurysm model in dogs for hemodynamic study and to do mor－phologic and hemodynamic assessment. Methods：Fourteen female beagle dogs were selected，seven taking the traditional vein patch to establish pseudoaneurysm were regarded as control group and the other seven taking new ‘pocket’ vein patch to establish pseu－doaneurysm model as experimental group. CT angiography examination was carried out immediately and on 7，14，30 d after the operation. Color Doppler ultrasound was carried out on 7 d after the operation. Morphologic and hemodynamic assessments were made. Results：Experimental animal survival rate was 100%. Local wall expansion rate at immediate postoperative period and at 7，14，30 d after the operation were （6.11±2.38）%，（26.14±7.14）%，（63.42±12.77）%，（88.26±14.42）% in control group while（199.39±14.92）%，（216.83±14.68）%，（239.30±16.75）%，（266.30±16.48）% in experiment group. Wall expansion rates were higher in experiment group than in control group at each observation point，with statistically significant differences. Conclusion：Adopting ‘pocket’ vein patch to establish infrarenal obdominal aortic pseudoaneurysm model in dogs is more in line with the morpho－logical and hemodynamic characteristics of the human pseudoaneurysm.