Survivin、MMP-2在乳腺癌中的表达及其相关性研究

Expression of Survivin and MMP-2 in breast carcinoma and their correlation

摘要:

目的：通过检测Survivin和基质金属蛋白酶2（Matrix metalloproteinase 2，MMP-2）在乳腺癌组织中的表达，研究两者的相关性及其在乳腺癌发生发展中的意义。方法：用免疫组织化学S-P法检测114例乳腺癌中Survivin、MMP-2的表达，分析其相关性及二者与乳腺癌临床分期、病理组织学分级、腋窝淋巴结转移、5年生存率的关系。结果：Survivin、MMP-2在乳腺癌中的阳性表达率分别为71.05%和75.40%，显著高于两者在正常乳腺中的表达率，且二者表达呈正相关（P<0.05）；并均与乳腺癌临床分期、病理组织学分级、腋窝淋巴结转移、5年生存率密切相关（P<0.05）。结论：Survivin、MMP-2基因表达与乳腺癌的发生发展密切相关，联合检测有助于乳腺癌预后的判断。

Abstract:

Objective：To discuss the relationship between and significance of the expressions of Survivin and MMP-2 in carcinogene－sis and progression of breast carcinoma through detection and investigation. Methods：The expressions of Survivin and MMP-2 in 114 cases breast carcinoma tissues were detected by immunohistochemistry SP method.The relationship between Survivin and MMP-2 was analyzed，and their correlations with clinical stage，tumor grade of differentiation，axillary lymph node metastasis，and 5-year disease-free survival were also studied. Results：The positive expression rates of Survivin and MMP-2 in breast carcinoma were 71.05% （81/114） and 75.40% （84/114），respectively，which were significantly higher than those in normal breast tissue.Survivin expression had a positive correlation with MMP-2.Both Survivin and MMP-2 were correlated with the clinical stage，pathology grade，axillary lymph nodes metastasis，and 5-year disease-free survival （P<0.05）. Conclusion：The expressions of Survivin and MMP-2 are significantly correlated with the occurrence and development of breast carcinoma. Detection of these two expressions may be valuable for evaluating the prognosis of breast carcinoma.