Objective:To explore the computed tomography(CT) feature of hypopharyngeal carcinoma and investigate its differentia-tion from other hypopharyngeal diseases. Methods:CT findings of 21 cases of hypopharyngeal carcinoma and other hypopharyngeal diseases which are necessary to differentiate from hypopharyngeal carcinoma were retrospectively analyzed,all of which were con-firmed by surgery or pathology. Results:Of 21 cases,there were 13 cases of hypopharyngeal carcinoma,5 cases of hypopharynx in-flammation,1 case of hypopharyngeal cyst,1 case of hypopharyngeal lymphoma and 1 case of hypopharyngeal polyp. Of the 13 cases of hypopharyngeal carcinoma,CT found location at pyriform sinus in 10 cases,at posterior wall of hypopharynx in 2 cases,at postcricoid in 1 case. The main manifestations of hypopharyngeal carcinoma were soft tissue density mass located at one side of pyri-form sinus or retropharynx or postcricoid,thickening of retropharyngeal soft tissue,inhomogeneous enhancement,usually widening of cricoid cartilage-vertebra or arytenoid cartilage-vertebra distance(≥1 cm),involving larynx and neighboring structures,parapharyngeal structures and adjacent cervical soft tissue,destructed laryngeal cartilage,invaded esophagus and metastasis of cervical lymph nodes. Conclusion:CT is useful for observing the site,shape,size and invasive extent of hypopharyngeal carcinoma as well as lymph node metastases.The widening of cricoid cartilage-vertebra or arytenoid cartilage-vertebra distance is the characteristic feature of hypopha-ryngeal carcinoma and necessary to differentiate from other hypopharyngeal diseases.