哌罗匹隆治疗原发性甲减所致精神障碍疗效观察

The curative effects observation of perospirone in the treatment of mental disorders caused by hypothyroidism

摘要:

【】目的：探讨哌罗匹隆治疗甲减所致精神障碍的疗效及安全性。方法：使用哌罗匹隆联合甲状腺素或左-甲状腺素钠片治疗甲减所致精神障碍34例,采用阳性和阴性症状量表(PANSS)及不良反应症状量表(TESS)于治疗前后进行评定,并在疗程结束后比较治疗前后血促甲状腺激素(TSH)、三碘甲状腺元氨酸（T3 ）、甲状腺素（T4）、游离三碘甲状腺元氨酸（FT3 ）、游离甲状腺素（FT4 ）的变化情况。结果：哌罗匹隆联合联合甲状腺素或左-甲状腺素钠片治疗后PANSS总分明显下降,治疗前与治疗后第2,4,8周比较差异有统计学意义(P<0.01)。病情疗效评定：总有效率77.5%。治疗后TSH、T3、T4、FT3、FT4明显好转,与治疗前比较,差异有统计学意义(P<0.01)。结论：哌罗匹隆是一种安全有效的抗精神病药物,对精神症状有显著的改善作用。联合治疗原发性甲减所致精神障碍病人是安全有效的。

Abstract:

Abstract：objective：To explore the clinical curative effects and safety of perospirone in the treatment of mental disorders caused by hypothyroidism. Methods：34 patients with mental disorders caused by hypothyroidism were treated by perospirone combined thyroxine,or left - levothyroxine sodium tablets. Before and after the treatment, the positive and negative symptom scale ( PANSS ) and adverse symptoms scale ( TESS ) were used to assess the curative effects.And compared the changes of blood thyroid stimulating hormone (TSH), iodine thyroid acid (T3), thyroxine (T4), free iodine thyroid acid (FT3) and free thyroxine (FT4) ,before and after treatment. Results：Treated by perospirone combined thyroxine,or left - levothyroxine sodium tablets, the PANSS total scores decreased significantly. Compared before treatment with 2, 4, 8 weeks after treatment, the differences were statistically significant (P <0.01). Disease efficacy evaluation: The total effective rate was 77.5%. After treatment, TSH, T3, T4, of FT3 and FT4 was significantly improved.Compared with before treatment, the difference was statistically significant (P < 0.01).Conclusion：Perospirone is a safe and effective antipsychotic medication, and make significant improvement in psychiatric symptoms. It is safe and effective in the treatment of mental disorders caused by primary hypothyroidism.