Objective:To discuss the causes of misdiagnosis of an intervertebral infection case and summarize experiences so as to avoid misdiagnosis. Methods:Causes of misdiagnosis were discussed and analyzed,and experiences were summarized based on the detailed clinical data. Results:Insufficient knowledge of intervertebral space infection,of which the incidence rate is low,and failure to analyze the case comprehensively and meticulously enough were the main causes of misdiagnosis. Conclusion:Patients should be highly considered the possibility of intervertebral space infection,who have fever and severe spastic low back pain with erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) increased,with MRI showing T1WI low signal and T2WI high signal lesion.