食管鳞癌中maspin及EIF-5A2的表达及临床意义

Expressions of maspin and EIF-5A2 in esophageal squamous cell carcinoma and their clinical significance

摘要:

目的：探讨maspin及EIF-5A2在食管鳞癌中的表达及意义。方法：应用免疫组化SP方法检测60例食管鳞癌组织中maspin及EIF-5A2的表达。结果：食管鳞癌中maspin蛋白的表达与病理分化程度及淋巴结转移有相关性（P=0.009、P=0.023），EIF-5A2的表达与肿瘤浸润深度、淋巴结转移及临床分期有相关性（P=0.001、P=0.027、P=0.005）。结论：maspin及EIF-5A2在食管鳞癌中的表达提示它们可作为判断食管鳞癌恶性程度，评估其侵袭性及转移的分子生物学指标;联合检测maspin及EIF-5A2可能对食管鳞癌早期诊断及判断预后有重要意义。

Abstract:

Objective:To investigate the expressions of maspin and EIF-5A2 in esophageal squamous cell carcinoma and the clinical significance. Methods：Immunohistochemical SP method was used to detecte the expressions of maspin and EIF-5A2 in 60 esophageal carcinoma tissues. Results：Maspin protein expression in esophageal squamous cell carcinoma tissues had a correlation with histologi－cal differentiation and lymph node metastasis（P<0.05），and EIF-5A2 expression in esophageal squamous cell carcinoma tissues had a correlation with invasion，lymph node metastasis and TNM staging（P<0.05）. Conclusion：The expressive intensity of maspin and EIF-5A2 in esophageal carcmoma tissue may be served as the molecular biological index of evaluating infilitration and metastasis. The combined examination of maspin and EIF-5A2 may be useful for the diagnosis of early esophageal squamous cell carcinoma and e－valuating prognosis in esophageal squamous cell carcinoma.