基于体素分析全脑弥散系数值测定在不同年龄组正常人中的应用

Application of voxel-based analysis to gain apparent diffusion coefficient in normal human brain in various age groups

摘要:

目的：利用弥散张量成像 （Diffusion tensor imaging，DTI） 基于体素分析（Voxel-based analysis，VBA）方法，探讨不同年龄组正常人群全脑表观弥散系数（Apparent diffusion coefficient，ADC）变化特点。方法：对正常青年人和老年人各60例行DTI检查。利用DTiStudio分析软件获得全脑平均表观弥散系数（Mean apparent diffusion coefficient，ADCmean）图，并用统计参数图 （Statistical parametric mapping，SPM）对2 组受试者的ADCmean图进行两样本t检验，观察正常老年人与青年人群比较后，全脑ADCmean值有显著性改变的脑区。结果：老年人相对于青年人脑内出现广泛ADC显著加快区域，包括前额叶眶回、前额叶内侧回、额上回、额中回，小脑前叶、小脑顶部、颞叶上回、中央前回、中央后回等（P<0.05）。结论：基于VBA的全脑ADC值测定，能较为敏感反映ADC值在不同年龄群中变化，为进一步研究老年人群颅内微结构改变提供途径。

Abstract:

Objective:To explore the apparent diffusion coefficient（ADC） feature in normal human brain in various age groups using diffusion tensor imaging（DTI） through voxel-based analysis（VBA） method. Methods:Sixty younger volunteers and sixty older volun－teers underwent DT1，and gained the ADCmean through DTiStudio．The ADCmean was compared by voxel-based analysis，and so were the areas of the brain with significant changes of the ADCmean between the two groups. Results:Compared with the younger vol－unteers，the older volunteers showed increased ADCmean in the bilateralis inferior frontal gyrus，middle frontal gyrus，superior frontal gyrus，middle temporal gyrus，superior temporal gyrus，cerebellum anterior lobe，culmen，precental and postcental gyrus and so on. Conclusion:The normal ADCmean values through VBA in various age groups measured quantitatively provide the changes between the two groups and can be used to explore the microstructure changes in the older.