Objective:To explore the variation factors in the implementation of clinical pathway in ST elevation myocardial infarction,so as to further improve the quality of clinical pathway implementation. Methods:In our hospital from March 2010 to September 2011,clinical path data of 203 cases of acute ST elevation myocardial infarction patients for were analyzed,and correction analysis was con-ducted to the variation analysis interrelated factors. Results:A total of 122 patients with 203 cases did not complete a clinical pathway (60.10%),the patient or family member factors in 114 cases (93.44%),medical personnel factor in 6 cases (4.92%),equipment factors in 2 cases(1.64%),which includes medical cost problems in 45 cases(36.89%),and complications in 42 cases(34.43%). Conclusion:Clinical pathway variations analysis for STEMI helps to find out the reasons for variation and to reduce variation. Clini-cal pathway can be smoothly fulfilled through timely and effective intervention,and by supplementing and completing the clinical pathway content,so as to improve the treatment and caring quality.