氨甲环酸对全髋关节置换术隐性失血的影响

Effect of tranexamic acid on the hidden blood loss after total hip arthroplasty

摘要:

目的：探讨氨甲环酸对单侧全髋关节置换术隐性失血的影响。方法：40例因单侧股骨颈骨折行全髋关节置换术患者随机分为2组。A组20例，不使用氨甲环酸，手术开始时予250 ml生理盐水静滴；B组20例，使用氨甲环酸，手术开始时将氨甲环酸按20 mg/kg稀释于250 ml生理盐水中静滴。分别计算其显性及隐性红细胞丢失量，并进行相应对比分析。结果：A组与B组显性红细胞丢失量分别为(95.43±17.72) ml和(48.84±15.04) ml（P＜0.05)；A组与B组隐性红细胞丢失量分别为(322.37±57.69) ml和(169.89±58.50) ml（P＜0.05)。结论：氨甲环酸能明显减少单侧全髋关节置换术的显性及隐性失血。

Abstract:

Objective: To assess the impact of tranexamic acid on the hidden blood loss after unilateral total hip arthroplasty.Methods:Totally 40 patients who received unilateral total hip arthroplasty due to femoral neck fracture were randomly divided into two groups.Group A included 20 cases without tranexamic acid,in which the patients were just given 250 ml normal saline when the surgery started; Group B included 20 cases with tranexamic acid,and the patients in this group were given 20 mg/kg tranexamic acid with 250 ml normal saline when the surgery started.The total red blood cell loss,visible red blood cell loss and hidden red blood cell loss of the two groups were measured and the comparative analysis was conducted.Results:Results of the visible red blood losses in group A and group B were (95.43±17.72)ml and (48.84±15.04)ml,respectively; the hidden red blood loss in group A and group B were (322.37±57.69)ml and (169.89±58.50) ml,respectively.The visible and hidden red blood cell losses in group B were both significantly less than those in group A(P<0.05).Conclusion:Tranexamic acid reduces both the visible and hidden red blood loss after the unilateral total hip arthroplasty.