血管迷走性晕厥不同治疗策略的近中期疗效评价

Middle-term efficacy evaluation on different treatment strategies for vasovagal syncope

摘要:

目的：结合不同影响因素探讨药物治疗与非药物治疗在血管迷走性晕厥（Vasovagal syncope，VVS）中的应用策略。方法：经直立倾斜试验确诊的54例中青年人群（18~46岁）VVS患者（其中女30例，男24例）根据性别分别随机分为非药物治疗组、β受体阻滞剂治疗组及安慰剂组。通过2个阶段共12个月的随访，分别针对时间、性别的不同，对VVS在治疗过程中发生率的变化进行统计学分析。结果：药物治疗对VVS长期疗效不佳，非药物治疗短期内患者收益较小，但远期疗效优势明显；药物治疗仅对女性VVS患者有作用，而非药物治疗则对两性VVS患者均有较显著的作用。结论：初步揭示了不同治疗手段在不同性别中对VVS长期发生率的影响，可能为临床VVS的治疗提供新的个体化解决方案及循证医学证据。

Abstract:

Objective:To investigate the drug treatment and non-drug treatment for vasovagal syncope (VVS) with different influence factors.Methods:Totally 54 patients (30 females and 24 males) with VVS diagnosed by head-up tilt testing were randomly divided into non drug treatment group,β-blocker treatment group and placebo group based on the sex.The incidences of VVS at different periods of the treatment and for different sexes were analyzed during the 12 months’ follow-up.Results:The long-term efficacy of the drug treatment for VVS was not satisfactory,however that of the non-drug treatment is good,although not obvious at short-term.The drug treatment was effective for females while the non drug treatment was conducive to both sexes.Conclusion:The study reveals the effects of different treatments methods on the incidences of VVS in different sexes,which may propose new individualized treating programs for VVS in clinics and provide references for evidence based medicine.