绝经后患者雌酮及其代谢物与乳腺癌的相关性

Correlation among estrone, its metabolites and breast cancer in postmenopausal women

摘要:

目的：探讨循环雌酮（Estrone,E1）、2-羟雌酮（2-hydroxyestrone,2-OHE1）、16α-羟雌酮（16α-hydroxyestrone，16α-OHE1）水平及2-OHE1∶16α-OHE1比值与绝经后乳腺癌的相关性。方法：采用ELISA法检测绝经后40例乳腺癌、21例乳腺纤维腺瘤和19例乳腺病患者循环E1、2-OHE1和16α-OHE1水平并计算2-OHE1∶16α-OHE1比值。结果：3组患者循环E1、16α-OHE1水平和2-OHE1∶16α-OHE1比值差异无统计学意义（P>0.05），3组患者2-OHE1水平差异有统计学意义（P<0.05），乳腺癌组较乳腺病组低，差异有统计学意义（P<0.05）。循环E1、2-OHE1、16α-OHE1水平和2-OHE1∶16α-OHE比值与雌激素受体(Estrogen receptor，ER）、人表皮生长因子受体2（HER2）情况、腋窝淋巴结转移情况以及肿瘤大小无关（P>0.05）。乳腺癌危险性与2-OHE1∶16α-OHE1比值无相关性［OR,0.828；95%CIfor exp(B)，0.425～1.611；P=0.578］，与2-OHE1呈负相关性［OR,0.418；95%CI for exp(B)，0.180～0.971；P=0.043］。结论：实验结果提示2-OHE1水平与乳腺癌危险性呈负相关，未发现2-OHE1∶16α-OHE1比值预示乳腺癌危险性。

Abstract:

Objective:To study the correlation among circulating estrone (E1), 2-hydroxyestrone(2-OHE1), 16α-hydroxyestrone(16α-OHE1), the ratio of 2-hydroxyestrone to 16α hydroxyestrone(2-OHE1∶16α-OHE1) and breast cancer in postmenopausal women. Methods:Serum levels of E1,2-OHE1,16α-OHE1 were measured by ELISA method in 40 cases of breast cancer,21 cases of breast fibroadenoma and 19 cases of mastopathy in postmenopausal women; the ratio of 2-OHE1 to 16α-OHE1 was calculated. Results:There were no significant difference in circulating levels of E1,16α-OHE1 and the ratio of 2-OHE1 to 16α-OHE1 in three groups (P＞0.05). The levels of 2-OHE1 were significantly different in three groups（P<0.05）; it’s level in breast cancer group was significantly lower than that in mastopathy group（P<0.05）. Circulating levels of E1,2-OHE1,16α-OHE1 and the ratios of 2-OHE1 to 16α-OHE1 were not associated with ER, HER2, axillary lymph node status or tumor size (P＞0.05). Breast cancer risk was not associated with the ratio of 2-OHE1 to 16α-OHE1(Odds ratio was 0.828, 95% confidence interval was 0.425~1.611, P＞0.05)，but it was negatively associated with the level of 2-OHE1(Odds ratio was 0.418, 95% confidence interval was 0.180~0.971, P<0.05).Conclusion：The results suggest that the level of 2-OHE1 is negatively associated with breast cancer risk, and do not support that the ratio of 2-OHE1 to 16α-OHE1 predicts breast cancer risk.