右美沙芬咀嚼胶给药系统的制备和质量评价

Preparation and quality evaluation of Dextromethorphan chewing gum drug delivery system

摘要:

目的：筛选出最佳的右美沙芬(Dextromethorphan，DM)咀嚼胶制剂处方，制备制剂并进行质量评价。方法：采用正交设计优化咀嚼胶制剂，压片法制备DM咀嚼胶制剂。结果：正交设计优化后的DM咀嚼胶制剂最佳处方为：胶基、阿斯巴甜、薄荷脑和香精的用量分别为90%、3%、0.5%和0.2%。结论：DM咀嚼胶制剂制备工艺合理，质量符合要求。

Abstract:

Objective:To select the best prescription for Dextromethorphan (DM) chewing gum preparation and to evaluate its quality. Methods: The DM chewing gum preparation was prepared by tablet press method; the formulation was optimized by orthogonal experiments.Results: The best prescription based on the results of orthogonal experiments was that the proportion of gum base,aspartame,menthol and essence was 90%,3%,0.5% and 0.2%,respectively. Conclusion: DM chewing gum preparation can be successfully formulated and its quality can be guaranteed.