脑梗死患者血清脂联素、 白介素-6与颈动脉内中膜厚度相关性研究

Correlations among serum adiponectin,interleukin-6 and intimal-medial thickness of the carotid artery in patients with cerebral infarction

摘要:

目的：探讨脑梗死患者血清脂联素、白介素-6（Interleukin-6，IL-6）与颈动脉内中膜厚度（Intimal-medial thickness，IMT）的相关性，及其在脑梗死发生发展过程中的意义。方法:以96例脑梗死患者为梗死组，50例健康志愿者为正常对照组。用酶联免疫吸附法（Enzyme-linked immunosorbent assay,ELISA）分别测定血清IL-6和血清脂联素水平；分别测量IMT值，并分为IMT＜1.0 mm和IMT≥1.0 mm两个亚组。结果：脑梗死组IMT≥1.0 mm者和IMT＜1.0 mm者，IL-6，脂联素含量分别与正常对照组相比差异均有统计学意义（P＜0.05）；脑梗死组中IMT≥1.0 mm者血清IL-6 脂联素含量与IMT＜1.0 mm者相比差异亦有统计学意义（P＜0.05）；脑梗死组患者IMT与血清IL-6含量呈明显正相关（R＝0.52，P＜0.01）,脑梗死患者IMT与血清脂联素含量呈明显负相关（R＝-0.848，P＜0.01）。结论:脑梗死患者IMT增厚，血清脂联素降低，IL-6升高，脑梗死患者IMT与血清脂联素，IL-6含量，具有明显相关性。

Abstract:

Objective:To investigate the correlations among serum adiponectin,interleukin-6(IL-6) and intimal-medial thickness(IMT) of the carotid artery in patients with cerebral infarction(CI) and to explore their significances in the development of cerebral infarction.Methods:Ninty-six patients with CI were enrolled as CI group and 50 healthy volunteers as control group.Serum adiponectin and serum IL-6 levels were detected respectively using enzyme-linked immunosorbent assay (ELISA).Carotid artery IMT was measured in both groups and the patients were subdivided into two groups based on the IMT value (greater or smaller than 1.0 mm).Results: There were significant differences in serum adiponectin and IL-6 levels between CI group and control group (P<0.05).The serum adiponectin and IL-6 levels were also significantly different between CI patients with carotid IMT equal to or greater than 1.0 mm and those with IMT smaller than 1.0 mm (P<0.05).In CI group,IMT was positively correlated with serum IL-6 level (R=0.52,P<0.01) but it was negatively correlated with serum adiponectin level (R=-0.848,P<0.01).Conclusion: IMT are increased and the level of serum adiponectin is reduced in patients with CI.The levels of IL-6,serum adiponectin and IMT in patients with CI are obviously correlated.