卵巢癌组织中HMGB1和E-cadherin的表达及其意义

Expression and significance of HMGB1 and E-cadherin in ovarian carcinoma

摘要:

目的：探讨高迁移率簇蛋白B1（High mobility group box-1，HMGB1）和上皮型钙黏素（E-cadherin） 在卵巢癌组织中的表达及临床意义。方法：选取我院妇产科2008年5月至2011年1月75例确诊为卵巢癌的患者为研究对象，采用免疫组化SP法染色，比较HMGB1和E-cadherin在卵巢癌组织及正常卵巢组织的表达差异，并分析不同临床病理参数下卵巢癌组织中HMGB1和E-cadherin的表达意义。结果：卵巢癌组织E-cadherin表达阳性率低于正常卵巢组织（χ2=12.62，P＜0.01）；卵巢癌组中HMGB1阳性表达率为（58/75）高于正常卵巢组织中表达（4/40）（χ2=47.60，P＜0.01）。HMGB1和E-cadherin的表达与卵巢癌病理类型和病理分级无关（P ＞0.05），与临床分期和有无淋巴结转移有关（P<0.05）。卵巢癌组织中HMGB1和E-cadherin的异常表达呈显著负相关（r=-0.299，P＜0.01）。结论：HMGB1和E-cadherin在卵巢癌发生、浸润、转移过程中起重要作用。

Abstract:

Objective：To explore the expression and clinical significance of high mobility group box-1（HMGB1） and E-cadherin in ovarian carcinoma. Methods：Between May 2008 and January 2011，immunohistochemical SP method was used to detect the expres－sion of HMGB1 and E-cadherin in 75 patients with ovarian carcinoma and 40 normal ovarian tissues and to analyze the clinical pathological significance of HMGB1 and E-cadherin in ovarian carcinoma. Results：The positive expression of E-cadherin was lower in ovarian carcinoma than in normal ovarian tissues（χ2=12.62，P＜0.01）. The positive expression of HMGB1 was higher in ovarian car－cinoma than in normal ovarian tissues（58/75 vs. 4/40， χ2=47.60，P＜0.01）. The expression pattern of HMGB1 and E-cadherin were associated with clinical stage and lymph node metastasis（P<0.05），but not with histological subtypes and histological stages（P ＞0.05）. The expression of HMGB1 was negatively correlated with E-cadherin（r=-0.299，P<0.01） in ovarian cancer. Conclusion：HMGB1 and E-cadherin might play an important role in the carcinogenesis and metastasis of ovarian carcinoma.