解痉鸡尾酒预防介入诊疗中桡动脉痉挛的对比研究

Comparative study of spasmolytic cocktail in preventing radial artery spasm during percutaneous coronary intervention through radial artery

摘要:

目的：对经桡动脉介入诊疗患者行硝酸甘油、单硝酸异山梨酯、地尔硫卓、维拉帕米不同药物组合干预，观察其预防桡动脉痉挛（Radial artery spasm，RAS）效果。方法：患者被随机分为3组：鞘管置入后A组予硝酸甘油200 μg+维拉帕米200 μg处理；B组予单硝酸异山梨酯5 mg+维拉帕米200 μg处理；C组予硝酸甘油200 μg+地尔硫卓2.5 mg处理，记录各组RAS发生率并进行比较。结果：RAS发生率A组小于C组，差别具有统计学意义（P<0.05）。结论：在桡动脉介入诊疗中，联合使用硝酸甘油200 μg+维拉帕米200 μg预防RAS更有效。

Abstract:

Objective：To compare the efficacy of spasmolytic cocktail composed of Nitroglycerin，Verapamil，Diltiazem and Isosorbide mononitrate in reducing the incidence of radial atery spasm in patients undergoing transradial coronary interventions. Methods：Pa－tients enrolled were randomly divided into three groups. After successful cannulation and sheath insertion into radial arteries，patients in group A received intra-aterial Nitroglycerin 200 μg and Verapamil 200 μg，patients in group B received Isosorbide mononitrate 5 mg and Verapamil 200 μg，patients in group C received Nitroglycerin 200 μg and Diltiazem 2.5 mg. Then the incidence of spasm was determined. Results：There were significant statistical differences between groups A and C（P<0.05）. Conclusion：Intra-arterial pre－medication with cocktail composed of 200 μg Nitroglycerin and 200 μg Verapamil is more effective in preventing radial spasms dur－ing percutaneous coronary interventions through radial artery.