我国四川、新疆两省HIV感染者固定性伴侣暴露前预防用药接受意愿分析

Analysis of the willingness to accept PrEP among regular sex partners of HIV-infected individuals in Sichuan and Xinjiang province of China

摘要:

【摘要】 目的 了解我国四川、新疆两省HIV感染者固定性伴侣(Regular sex partners,PAR)对暴露前预防用药(Pre-exposure Prophylaxis,PrEP)的接受意愿及其影响因素。方法 采用非随机抽样,对473位合格的研究对象进行面对面匿名问卷调查。采用 检验进行单因素分析,利用logistic回归进行多因素分析。结果 我国四川、新疆两省的PAR对PrEP的知晓率不高,85.41%从未听说过PrEP,调查人员对PAR人群进行PrEP相关内容的讲解后,PrEP的接受意愿达到了80.34%。经Logistic回归分析,PAR人群PrEP接受意愿的影响因素包括民族(维吾尔/汉族：OR=2.471,P=0.0093)、月收入水平(<=1000元/1001元-3000元：OR=2.046,P=0.0184)、半年内是否与配偶发生过性行为(是/否：OR=2.263,P=0.0192)、自认为从配偶处感染HIV的可能性(可能性一般/大：OR=0.485,P=0.0651；可能性小/大：OR=0.447,P=0.0273)、是否建议朋友使用PrEP(会/不会：OR=9.416,P<.0001)、配偶查出感染HIV的时间(三年之内/一年内：OR=0.478,P=0.0599；三年前/一年内：OR=0.374,P=0.0094)。结论 我国四川、新疆两省的PAR对PrEP的知晓率低,接受意愿高,在今后的艾滋病干预工作中,应加大PrEP的宣传力度,提高其知晓率,进一步提高接受意愿。同时,不妨尝试在该人群中开展同伴教育,这可能是推广PrEP的有效方式。

Abstract:

objective To investigate the willingness to accept PrEP and its influencing factors among regular sex partners of HIV-infected individuals in Sichuan and Xinjiang province . Methods Face-to-face anonymous questionnaire was conducted to 473 qualified objects by non-randomly sampling method. test was employed to conduct univariate analysis, multivariate analysis was conducted using logistic regression .Results Awareness of PrEP among PAR was not high in Sichuan and Xinjiang province, 85.41% had never heard of PrEP, but reached to 80.34% after being taught on PrEP related knowledges by investigators. Logistic regression showed that the multiple influencing factors of the willingness to accept PrEP among PAR population were nation (Uyghur / Han:OR=2.471,P=0.0093), monthly income levels(<= 1000/1001-3000: OR = 2.046, P =0.0184), whether have sex with spouse within six months (yes / no: OR = 2.263, P = 0.0192), self-awareness of the possibility to be infected with HIV from their spouses (medium possibility/great: OR=0.485,P=0.0651；low possibility/great:OR=0.447,P=0.0273), whether would recommend friends to use PrEP (would / would not: OR = 9.416, P <.0001), the time when the spouse was diagnosed with HIV infection (within three years /one year: OR = 0.478, P = 0.0599; three years ago / within one year: OR = 0.374, P =0 .0094).Conlusion Awareness of PrEP among PAR was not high in Sichuan and Xinjiang province, but with a high rate of willingness to accept, propaganda of PrEP in AIDs intervention should be strengthened in the future thus to improve their awareness of PrEP and their willingness to accept PrEP. In the meanwhile, peer education could be possibly carried out among this population which might be an effective way to promote PrEP.