胃血管球瘤6例临床病理分析

Clinicopathological analysis of stomach glomus tumor in 6 cases

摘要:

目的：探讨胃血管球瘤的临床病理特征、鉴别诊断和预后。方法：复习6例胃血管球瘤的临床资料，进行组织形态和免疫组化观察。结果：5例为良性胃血管球瘤，1例为有难以预测的潜在恶性的胃血管球瘤。肿瘤细胞大小一致，圆形或多角形，胞质丰富红染或透亮，围绕血管排列。免疫组化抗平滑肌抗体（Smooth muscle antibody，SMA）、actin、laminin、Vimentin阳性表达，而CD34、CD117、神经元特异性烯醇化酶（Neuron specific enolase，NSE）及AE1/AE3、Anti-cytokeratin（CAM5.2）、癌胚抗原（Car－cino－embryonic antigen，CEA）等均阴性表达。结论：胃血管球瘤较少见，绝大部分为良性，临床、细胞学及冷冻快速病理检查均易误诊，应提高对该疾病的认识，减少不必要的扩大手术。

Abstract:

Objectve：To investigate the clinicopathological characteristics，differential diagnosis and prognosis of stomach glomus tu－mors. Methods：Totally 6 cases of stomach glomus tumors were studied by histopathological observation and immunohistochemical staining. Results：The study included 5 cases of benign tumors and 1 case of potential malignant stomach glomus tumor which was hard to predict. The tumor cells were uniform-sized，round or polygonel，arranged around the blood vessels. Immunohistochemical study demonstrated that tumor cells reacted positively to Vimentin，smooth muscle antibody（SMA），laminin，actin，but negatively to CD34，CD117，neuron specific enolase（NSE），AE1/AE3，CAM5.2 and carcino－embryonic antigen（CEA）. Conclusions：Stomach glo－mus tumor is rare and most of the time benign. It can be easily misdiagnosed by frozen section and clinical and cytological tests so that more attention should be paid on the disease and unnecessary surgical therapies should be reduced.