免疫性慢性非细菌性前列腺炎大鼠的尿动力学研究

Urodynamics study of rats with immunological chronic nonbacterial prostatitis

摘要:

目的：观察慢性非细菌性前列腺炎大鼠的慢性炎症病理变化和尿动力学改变。方法：成年SD雄性大鼠，随机分为4组，每组5只。建立免疫性慢性非细菌性前列腺炎大鼠模型，第45、60、90天在麻醉状态下行尿动力学检查后灌流固定取材检查，并作病理学分析。结果：模型组大鼠表现为慢性非细菌性前列腺炎病理学变化。与正常对照组相比，45 d模型组排泄容积、最大排尿量和顺应性降低，排尿间隔缩短，60 d模型组残余容积和最大膀胱压增加，90 d模型组排泄容积降低，残余容积和顺应性增加，排尿间隔缩短，差别有显著性（P<0.05）。结论：慢性非细菌性前列腺炎动物模型存在尿动力学改变，其机制有待进一步研究。

Abstract:

Objective：To observe the pathological responses of chronic inflammation and urodynamic changes of the rats with chronic nonbacterial prostatitis（CNP）. Methods：Twenty male SD rats were equally divided into 4 groups（n=5）. After the experimental CNP rat model was established，the urodynamical recordings and histopathological analysis were done on the 45th，60th d and 90th d. Re－sults：Prostatic inflammation was induced in model group. Mic－turition volume（MV），maximal micturition volume（Max MV），vesical compliance（VC） and micturition interval（MI） were sig－nificantly deceased in model group than in normal control group on the 45th d （P<0.05）. Post void residual（PVR） and maximal bladder pressure were increased in model group than in normal control group on the 60th d（P<0.05）. MV was decreased，PVR and VC were increased and MI was shortened in model group than in normal control group on the 90th d （P<0.05）. Conclusion：Urodynamic changes are existed in CNP model and its mechanism needs further study.