年轻女性乳腺癌中ER、PR、HER-2和Ki67的表达与临床病理意义

Expressions and clinical significances of ER，PR，HER-2 and Ki67 in young women with breast carcinoma

摘要:

目的：探讨雌激素受体（Estrogen receptor，ER）、孕激素受体（Progesterone receptor，PR）、人表皮生长因子受体-2（Hu－man epidemic growth factor receptor-2，HER-2）和Ki67在新疆地区年轻女性（≤35岁）乳腺癌（Breast carcinoma，BC）患者中的表达及其与临床病理特征的关系。方法：应用免疫组化法检测70例年轻女性BC组织中ER、PR、HER-2和Ki67的表达情况，分析其表达与临床病理特征的关系。结果：（1）70例年轻女性BC中，ER、PR、HER-2和Ki67的阳性率分别为74.3%（52/70）、71.40%（50/70）、32.90%（23/70）和97.1%（68/70）；（2）HER-2表达在肿瘤大小及淋巴结转移各组中的差异有统计学意义（P<0.05）；Ki67表达在民族、组织学分级和淋巴结转移各组中的差异有统计学意义（P<0.05）；（3）ER、PR表达在民族、组织学分级、肿瘤大小及淋巴结转移各组中的差异均无统计学意义（P ＞0.05）；HER-2表达在民族和组织学分级各组中的差异均无统计学意义（P ＞0.05）；Ki67表达在肿瘤大小组中的差异均无统计学意义（P ＞0.05）。结论：（1）ER、PR在年轻女性BC中表达较高，其表达与临床病理特征无关；（2）HER-2和Ki67表达与年轻女性BC恶性度分级和转移有关；（3）Ki67在年轻女性BC中表达较高，且在不同民族中的表达存在差异；（4）联合检测ER、PR、HER-2和Ki67可作为判定年轻女性ＢＣ生物学行为和预后的参考指标。

Abstract:

Objective：To discuss the expressions of estrogen receptor（ER），progesterone receptor（PR），human epidemic receptor-2 （HER-2） and Ki67 in young women（≤35 years old） with breast carcinoma in Xinjiang and to explore the relationship between the expressions and the clinical pathological characteristics. Methods：The expressions of ER，PR，HER-2 and Ki67 in 70 young women with breast cancer were detected by immunohistochemical method and their relationship with the clinical pathological characteristics was analyzed. Results：The positive rate of ER，PR，HER-2 and Ki67 in 70 young women with breast carcinoma of were 74.3%（52/70），71.40%（50/70），32.90%（23/70） and 97.1%（68/70）. Statistical differences in the expressions of HER-2 were observed in groups with different tumor sizes and groups with or without lymph node metastasis（P<0.05）；statistical differences in the expressions of Ki67 were observed in groups with different nationalities and histological gradings and groups with or without lymph node metasta－sis（P<0.05）. No statistical difference in the expression of ER and PR was observed in groups with different nationalities and histologi－cal gradings，groups with different tumor sizes and groups with or without lymph node metastasis（P >0.05）；no statistical difference in the expression of HER-2 was observed in groups with different nationalities and histological gradings（P >0.05）；no statistical difference in the expression of Ki67 was observed in groups with different tumor sizes（P >0.05）. Conclusions：（1）The expressions of ER and PR in young women with breast carcinoma are high，but the expressions are not related with clinical pathological features.（2）The expres－sions of HER-2 and Ki67 are related with malignancy grading and metastasis. （3）The expressions of Ki67 are high and show vari－ances in groups with different nationalities. （4）Combined detection of ER，PR，HER-2 and Ki67 can be used as criterion of biologi－cal behavior and prognosis in young women with breast carcinoma.