儿童生存质量量表PedsQLTM 3.0神经肌肉疾病模块中文版的信度和效度分析

Reliability and validity for Chinese version of pediatric quality of life inventoryTM （PedsQLTM） 3.0 neuromuscular module

摘要:

目的：考察儿童生存质量量表PedsQLTM 3.0神经肌肉疾病模块（Pediatric quality of life inventoryTM 3.0 neuromuscular module，PedsQLTM 3.0 NMM）中文版的信度和效度。方法：采用规范的量表引进程序，将英文版的PedsQLTM 3.0 NMM翻译改造成中文，并应用于39例Duchenne型肌营养不良（Duchenne muscular dystrophy，DMD）患儿及其家长。分析量表的可行性、内部一致性、内容效度、结构效度等。结果：39份问卷中，父母代评量表及儿童自评量表的缺失率为0.31%、0.64%，均<1%。量表总分及各维度的克伦巴赫系数α（Cronbach’s α）介于 0.74～0.88，均>0.7；评定者间的信度（Intraclass correlation coefficient，ICC）介于0.74～0.86，均>0.6。量表各条目与所属维度的Spearman相关系数（rs）分别为0.42～0.88和0.39～0.84，均呈中、高度相关，而与其他维度的相关较弱。不同病情的疾病维度差异有统计学意义（P<0.05），余维度差异无统计学意义（P >0.05）。实证性因子分析结果显示相对拟合指数（Comparative fit index，CFI）分别为 0.94、0.93，均>0.9。结论：PedsQLTM 3.0 NMM中文版具有较好的信度和效度，可应用于中国神经肌肉疾病患儿生存质量的评价。

Abstract:

Objective：To evaluate the reliability and validity for Chinese version of pediatric quality of life inventoryTM 3.0 neu－romuscular module（PedsQLTM 3.0 NMM）. Methods：The standard procedure of cross-culture adaptation was used to develop the Chi－nese version PedsQLTM 3.0 NMM. Thirty-nine children with Duchenne muscular dystrophy（DMD） and their parents were investigated with the Chinese version scale. The feasibility，reliability and validity of the Chinese version scale were then evaluated. Results：Total－ly 39 copies of questionnaires were completed. The rates of item missing were 0.31% and 0.64%，less than 1%. Total and all dimen－sion’s Cronbach alpha coefficients were ranged between 0.74 and 0.88，all larger than 0.7 and the intraclass correlation coefficient（ICC） was ranged between 0.74 and 0.86，all larger than 0.6. The item in the PedsQLTM 3.0 NMM was moderately and highly related with correlation coefficient of Spearman（0.42～0.88 and 0.39～0.84） in its belonged domains than in other domains. Significant dif－ferences were observed in domains of disease with different severities（P<0.05） but no significant difference was observed in other domains（P >0.05）. Confirmatory factor analysis showed that the comparative fit indexes were 0.94 and 0.93. Conclusions：The Chi－nese version PedsQLTM 3.0 NMM has acceptable psychometric properties. The instrument may be a valuable tool to measure health-related quality of life（HRQOL） of Chinese children with neuromuscular diseases.