Objective:To explore the clinical features and treatment of primary empty sella turcica syndrome(PESS). Methods:The clinical data of 33 patients with PESS were analyzed retrospectively and pertinent literatures were reviewed. Results:Some patients (about 42.4%) had no correlative symptoms. The common symptoms were headache,dizziness,hypopsia,visual field defect and crypt-orrhea. Most patients did not need therapy. Conclusions:The clinical symptom of PESS in most patients is not typical and the diag-nosis depends on imaging data. Most patients do not need therapy.