Ebp1、雄激素受体在前列腺癌中表达及相关性研究

Expressions and correlations of Ebp1 and androgen receptor in prostate cancer

摘要:

目的：检测良性前列腺增生（Benign prostatic hyperplasia，BPH）和前列腺癌（Prostate cancer，PCa）中Ebp1（ErbB-3 binding protein，Ebp1）和雄激素受体（Androgen receptor，AR）的表达，并分析其与PCa分级、前列腺特异性抗原（Prostate specific antigen，PSA）水平、分期的相互关系。方法：21例 BPH，55例 PCa，采用免疫组织化学（SP法）检测Ebp1、AR的表达情况，并分析二者在BPH、PCa中的表达关系，二者表达与PCa的病理分级、术前PSA水平、临床分期的关系。结果：PCa组织中Ebp1的阳性表达明显低于BPH组织（P<0.05），BPH、PCa组织中AR的阳性表达无明显差异（P >0.05），PCa组织中Ebp1、AR的表达与病理分级、临床分期密切相关（P<0.05），与PSA值无明显关系（P >0.05）；PCa组织中Ebp1、AR在的表达存在正相关关系（P<0.05）。结论：Ebp1表达在 BPH、PCa组织中有差异性，Ebp1可以作为诊断前列腺癌的一个潜在指标；随着PCa进展AR、Ebp1表达逐步减少，二者的表达存在正相关关系，两者结合可作为PCa预后评价的指标。

Abstract:

Objective：To detect the expressions of Ebp1 and androgen receptor（AR） in benign prostatic hyperplasia（BPH） and prostate cancer（PCa） and to analyze their relationship with pathological grade of PCa，level of prostate specific antigen（PSA） and clinical stage. Methods：The expressions of Ebp1 and AR in 21 specimens of BPH and 55 specimens of PCa were detected by im－munohistochemistry. The differences of Ebp1 and AR expressions in BPH and PCa at different clinical stages，preoperative PSA levels，pathological grades of PCa were analyzed and their correlations were studied. Results：The positive rate of Ebp1 was significantly higher in PCa than in BPH tissues（P<0.05），and that of AR showed no significant differences between BPH and PCa groups（P >0.05）. Both the expressions of Ebp1 and AR were closely related with the pathological grade and clinical stage of PCa（P<0.05），but not with PSA level（P >0.05）. There was a positive correlation between expressions of Ebp1 and AR in PCa tissues（P<0.05）. Conclu－sions：Ebp1 is expressed differently in BPH and PCa. Ebp1 might become an indicator for the differential diagnosis of PCa. With the progression of PCa，the expressions of AR and Ebp1 are gradu－ally reduced，with positive correlation between them，which could be used jointly to evaluate the prognosis of PCa.