KAI1和Smad4在非小细胞肺癌的表达及临床病理意义

Expression and clinical pathological significance of KAI1 and Smad4 protein in non-small cell lung carcinoma

摘要:

目的：研究KAI1和Smad4蛋白在非小细胞癌（Non-small cell lung carcinoma，NSCLC）组织中的表达及其相关性，探讨其临床病理意义和作用。方法：应用免疫组织化学SP法检测150例NSCLC组织及60例对应的正常肺组织中KAI1和Smad4蛋白的表达，并与临床病理特征及预后进行分析，观察其表达差别及相关性。结果：KAI1和Smad4蛋白在NSCLC中表达的阳性率分别为26%和29.33%，在正常肺组织中的阳性率分别为66.67%和75%，差异有统计学意义（P<0.000 1）。在NSCLC中KAI1蛋白在淋巴结转移、临床分期晚的肿瘤中低表达（P<0.000 1）；Smad4蛋白在分化差、淋巴结转移、胸膜侵犯及临床分期晚的肿瘤中低表达（P<0.000 1）。但KAI1和Smad4无相关性（P >0.05）。KAI1和Smad4蛋白低表达的病人生存期较短（P<0.05）。结论：KAI1和Smad4蛋白在NSCLC中表达减少，可能参与肿瘤的发生及发展。术后检测KAI1和Smad4蛋白可能对判断预后有一定价值。

Abstract:

Objective：To investigate the expressions and correlations of KAI1 and Smad4 protein in non-small cell lung carcinoma （NSCLC） and to study their pathological significance and function in NSCLC. Methods：Totally 150 cases of NSCLC were chosen as experimental group and 60 cases of normal lung tissues as control group. The expressions of KAI1 and Smad4 protein were examined by immunohistochemistry and were analyzed along with their clinical pathological characteristics and prognosis of NSCLC in order to observe the differences in expressions and correlations among them. Results：The expressions of KAI1 and Smad4 were lower in ex－perimental group than in control group（P<0.000 1）. The expressions of KAI1 and Smad4 were correlated with differentiation，lymph node metastasis，pleural invasion and clinical stage（P<0.000 1）. The expressions of KAI1 and Smad4 were correlated with prognosis of NSCLC（P<0.000 1）. Conclusions：The lower expressions of KAI1 and Smad4 can promote the occurrence and development of NSCLC. The combined detection of KAI1 and Smad4 protein postoperatively might be helpful to predict the prognosis of NSCLC.