强迫症患者反应控制能力研究

Research on response control ability of patients with obsessive compulsive disorder

摘要:

目的：探讨强迫症（Obsessive-compulsive disorder，OCD）患者反应控制障碍。方法：运用停止信号任务，比较21例OCD患者与23例年龄匹配健康者的停止信号反应时（Stop signal reaction time，SSRT）和非停止信号反应时（No-signal reaction time，NSRT）等。结果：患者的SSRT和NSRT [（376.20±71.92） ms；（804.33±107.82） ms]均分别较健康对照[（304.13±76.73） ms；（714.98±97.01） ms]显著延长：t=3.206，P=0.003；t=2.894，P=0.006。运用协方差分析去除NSRT影响，两组间SSRT差异仍显著：F=22.518，P=0.000。分别对两组SSRT与停止信号任务的其余指标以及Y-BOCS分数进行了逐步线性回归分析。结论：OCD病人反应抑制和反应执行能力均明显下降。

Abstract:

Objective：To evaluate the response control function of patients suffering from obsessive compulsive disorder（OCD）. Meth－ods：Twenty-one OCD patients and 23 healthy controls were enrolled. All patients and healthy controls performed the stop- signal task which provides the indications reflecting the ability of response inhibition：stop signal reaction time（SSRT） and no-signal reaction time（NSRT）. The results of the two groups were ana－lyzed and compared. Results：Both SSRT （376.20±71.92） ms and NSRT （804.33±07.82） ms of OCD group were significantly longer than those of control group （304.13±76.73） ms，（714.98±97.01） ms：t=3.206，P=0.003；t=2.894，P=0.006. After the removal of the influence of NSRT by covariance analysis，the significant difference of SSRT between the two group was still found：F=22.518，P=0.000. The stepwise multiple regression analysis was carried out for SSRT and the other indexes of the task and Y-BOCS score. Con－clusion：The ability of both response inhibition and response executive of OCD patients was significantly decreased.