Objective:To observe the effectiveness and safety of applying continuous epidural block combined with basal anesthesia in pediatric inguinal region operation. Methods:Totally 60 children requiring operation in inguinal region were randomly divided into group A and group B. Continuous epidural block anesthesia combined with basal anesthesia was used in group A while Ketamine in-tramuscular basal anesthesia combined with Ketamine and Midazolam intravenous anesthesia was applied in group B. Results:The operation was successful in both groups. The Ketamine dosage and adverse reaction in reviving period were better in group A than in group B with statistical significances(P<0.01). Conclusions:With advantages of quicker postoperative awaking time,lower cost and safety,pediatric continuous epidural block combined with basal anesthesia is worth popularizing.