真菌性鼻鼻窦炎发病相关因素及病理分型研究

Correlative factors and pathological types of fungal rhino-sinusitis

摘要:

目的：探讨真菌性鼻鼻窦炎（fungal rhinosinusitis，FRS）的发病相关因素和病理分型。方法：对163例FRS患者的临床资料进行回顾性对照研究，采用非条件Logistic逐步回归分析方法，回顾性分析FRS发病的危险因素，筛查分析其发生的危险因素。对所有FRS患者，窦腔取材后采用真菌特异性六胺银染色方法进行了病理分型。结果：FRS发病的危险因素主要有年龄较大（≥50岁）、女性、涕血、头痛、有钙化斑，并发糖尿病等。163例FRS患者中，61例为侵袭性、102例为非侵袭性。FRS的真菌培养阳性率为：93.86%，正常对照组真菌培养阳性为22.38%，两组之间的差别有统计学意义（P<0.05）。结论：FRS的发病有诸多相关因素，结合FRS的相关因素和不同病理分型，采取有效的治疗措施，可以提高FRS的治疗效果。

Abstract:

Objective：To investigate the correlative factors and pathological types of fungal rhinosinusitis（FRS）. Methods：Clinical data of 163 patients with FRS enrolled between June 2005 and March 2010 in our hospital were retrospectively analyzed. Correlative factors and clinical features of FRS were investigated by using the multiple factor Logistic regression analysis. Pathological types of 163 cases of FRS were classified by using Gomori methenamine silvers taining，which was special for fungi. Results：Main risk factors for FRS were：over 50-year-old，female，hemato nasal discharge，headache，calcified plaque in CT scan，diabetes respectively. Among163 cases of FRS，61 cases were chronic invasive and 102 cases were non-invasive. Positive rate of fungal culture in patients with FRS was 93.86% and in normal controls was 22.38%，with statistical differences between them（P<0.05）. Conclusions：FRS has lots of cor－relative factors. We should take different treatment schemes for different patients based on their pathological types and correlative fac－tors of FRS in order to improve the therapeutic effects for FRS.