血浆E-FABP与FASN蛋白水平与人股动脉粥样硬化关系

Relationship of plasma E-FABP and FASN with atherosclerosis of human femoral artery

摘要:

目的：探讨血浆表皮型脂肪酸结合蛋白（epidermal fatty acid binding protein，E-FABP）与脂肪酸合成酶（fatty acid syn－thase，FASN）蛋白水平与人股动脉粥样硬化（atherosclerosis，ＡＳ）及相关危险因素的关系。方法：对178例患者行股动脉彩超检查并测定股动脉内膜中层厚度（intimal medial thickness，IMT），根据股动脉 IMT 分为股ＡＳ组（128例）和对照组（50例），测定空腹血浆 E-FABP、FASN 蛋白水平，分析其与股ＡＳ及危险因素的关系。结果：与对照组比较，股ＡＳ患者血浆中E-FABP与FASN蛋白水平增高（P<0.05），血浆 E-FABP 与 FASN 水平呈正相关（P<0.05），血浆 E-FABP水平与 年龄、体质指数（body mass index，ＢＭＩ）、甘油三酯（triglyceride，TG）、脂联素、Ｃ反应蛋白（C reactive protein，CRP）、IMT 呈正相关（P<0.05），血浆 FASN 水平与年龄，BMI、空腹血糖（fasting blood-glucose，FPG）、稳态模型胰岛素抵抗指数（homeostasis model assessment-insulin resistance index，HOMA-IR）、TG、脂联素、CRP、IMT呈正相关（P<0.05），血浆 E-FABP、FASN 与高密度脂蛋白-胆固醇呈负相关（P<0.05）；Logistic回归分析表明：年龄，FASN，E-FABP，HOMA-IR，CRP，TG 是股ＡＳ的危险因素（P<0.05）。结论：股ＡＳ与血浆 E-FABP、FASN水平相关联，可能成为新的诊断与评价人股ＡＳ的循环标志。

Abstract:

Objective：To investigate the relationship of plasma protein levels of epidermal fatty acid binding protein（E-FABP） and fatty acid synthase（FASN） with risk factors of human femoral atherosclerosis. Methods：One hundred and seventy-eight patients were detected by color Doppler with intimal-media thickness（IMT） measurement. Then，patients were divided into femoral atherosclerosis group（n=128） and control group（n=50） according to IMT. Fasting protein levels of E-FABP and FASN in plasma were detected and their relationship with femoral atherosclerotic risk factors was measured. Results：Plasma protein levels of E-FABP and FASN in atherosclerotic group were increased compared with those in control group（P<0.05）. Correlation analysis showed that there was a pos－itive correlation between plasma levels of E-FABP and FASN（P<0.05）. E-FABP level was correlated positively with age，body mass index（BMI），triglyceride（TG），adiponection，C reactive protein（CRP） and IMT（P<0.05）. FASN level was correlated positively with age，BMI，fasting plasma glucose，homeostasis model assessment-insulin resistance（HOMA-IR），TG，adiponectin，CRP and IMT（P<0.05）. Plasma levels of E-FABP and FASN were negatively correlated with high-density lipoprotein-cholesterol（P<0.05）. Logistic re－gression analysis showed that age，FASN，E-FABP，HOMA-IR，CRP and TG were the risk factors of femoral atherosclerosis（P<0.05）. Conclusions：Femoral atherosclerosis associated with plasma levels of E-FABP and FASN，which maybe a new circulating biomarker in diagnosis and evaluation of human femoral atherosclerosis.