银屑病及银屑病伴代谢综合征患者血清瘦素水平及意义

Serum leptin level in psoriasis and psoriasis with metabolic syndrome and its significance

摘要:

目的：观察瘦素在银屑病及银屑病伴代谢综合征（metabolic syndrome，MS）患者治疗前后血清中水平的变化，分析其临床意义。方法：收集66例寻常型银屑病患者身高、体质量、银屑病面积与严重程度指数、空腹血糖、血压、血脂和伴发MS等资料；根据患者有无MS分为两组并检测其血清瘦素水平，均与正常对照组比较。结果：发现银屑病伴MS者病程较不伴MS者长且对常规治疗效果欠佳；两组患者血清瘦素水平均高于正常组（P=0.000），而伴MS组瘦素水平更高；治疗后发现银屑病合并MS者瘦素水平下降不明显（P=0.209），而不伴MS者瘦素水平则有显著下降（P=0.000）。结论：银屑病伴MS者对常规治疗效果欠佳，瘦素可能参与了银屑病伴MS对治疗的抵抗。

Abstract:

Objective：To observe the level of serum leptin in psoriasis and psoriasis with metabolic syndrome（MS） before and after the treatment and to analyze its clinical significance. Methods：Data of height，weight，waistline，psoriasis area and severity index，fasting plasma glucose，blood pressure，blood lipid and MS of psoriasis patients were collected. Patients were divided into two groups according to whether they were suffering from MS. Serum leptin of patients was tested and compared with that of normal group. Results：Duration of psoriasis with MS was longer than that without MS，and patients with MS had poor treatment effect. Before treatment，serum leptin level was higher in all psoriasis patients than in normal controls（P=0.000） and leptin level was the highest in psoriasis with MS. After treatment，leptin level was decreased slightly in psoriasis with MS（P=0.209），but was significantly decreased in psoriasis without MS（P=0.000）. Conclusions：Traditional treatment is ineffective for psoriasis with MS and leptin may involve in the resistance.